Article
Linkage disequilibrium between an allele at the dopamine D4 receptor locus and Tourette syndrome, by the transmission-disequilibrium test.
American journal of human genetics - 1 Sept 1996
Grice D E, Leckman J F, Pauls D L, Kurlan R, Kidd K K, Pakstis A J, Chang F M, Buxbaum J D, Cohen D J, Gelernter J
Abstract excerpt
Dopaminergic abnormalities are implicated in the pathogenesis of Tourette syndrome (TS) and chronic multiple tics. We used the transmission-disequilibrium test (TDT) method to test for linkage disequilibrium between a specific allele (the seven-repeat allele (DRD4*7R) of the exon 3 VNTR polymorph...
Topics
- Alleles
- Child
- Chronic Disease
- Computer Simulation
- Exons
- Female
- Genotype
- Humans
- Linkage Disequilibrium
- Male
- Minisatellite Repeats
- Models, Genetic
- Obsessive-Compulsive Disorder
- Pedigree
- Receptors, Dopamine D2