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Article

Age-specific patterns of genetic variance in Drosophila melanogaster. I. Mortality.

Genetics - 1 Jun 1996

Promislow D E, Tatar M, Khazaeli A A, Curtsinger J W

Abstract excerpt

PETER MEDAWAR proposed that senescence arises from an age-related decline in the force of selection, which allows late-acting deleterious mutations to accumulate. Subsequent workers have suggested that mutation accumulation could produce an age-related increase in additive genetic variance (VA) for fitness traits, as recently found in Drosophila melanogaster. Here we report results from a genetic analysis of...

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Identifiers

PMID: 8725232
DOI: 10.1093/genetics/143.2.839
PMCID: PMC1207342

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