Article
Comparative effects of insulin-like growth factor II (IGF-II) and IGF-II mutants specific for IGF-II/CIM6-P or IGF-I receptors on in vitro hematopoiesis.
Stem cells (Dayton, Ohio) - 1 May 1996
Schwartz G N, Warren M K, Sakano K, Szabo J M, Kessler S W, Pashapour A, Gress R E, Perdue J F
Abstract excerpt
This report presents the results of studies investigating the effect of insulin-like growth factor II (IGF-II) on the proliferation and differentiation of CD34+ bone marrow cells in serum-substituted liquid cultures. Bone marrow cells were enriched for CD34+ cells and then placed in liquid cultures supplemented with either interleukin 3 (IL-3) or IL-3 and c-kit ligand with and without the addition of IGF-II. When...
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