Article
5 alpha-reduced androgens play a key role in murine parturition.
Molecular endocrinology (Baltimore, Md.) - 1 Apr 1996
Mahendroo M S, Cala K M, Russell D W
Abstract excerpt
Two steroid 5 alpha-reductase isozymes designated type 1 and 2 synthesize 5 alpha-reduced androgens and other 5 alpha-reduced steroid hormones. Naturally occurring mutations in the gene encoding 5 alpha-reductase type 2 cause male pseudohermaphroditism, indicating that this isozyme is responsible for the synthesis of dihydrotestosterone required for virilization of the embryonic male urogenital tract. To...
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