Article
Equianalgesic doses of subcutaneous but not intrathecal morphine alter phenotypic expression of cell surface markers and mitogen-induced proliferation in rat lymphocytes.
Anesthesiology - 1 Aug 1996
Hamra J G, Yaksh T L
Abstract excerpt
BACKGROUND: Surgical trauma and opioids are linked with suppression of immune function. Evidence suggests a probable supraspinal action of morphine in altering immune function, although the role of spinal systems have not been evaluated. Therefore, this study compared the effect of equianalgesic...
Topics
- Analgesics, Opioid
- Animals
- B-Lymphocytes
- Blood Pressure
- CD4 Antigens
- CD4-Positive T-Lymphocytes
- CD8 Antigens
- CD8-Positive T-Lymphocytes
- Carbon Dioxide
- Injections, Spinal
- Injections, Subcutaneous
- Lymphocyte Activation
- Lymphocyte Subsets
- Male
- Mitogens
- Morphine
- Partial Pressure
- Phenotype