Effects of morphine on the phenotypic expression of cell surface markers on murine lymphocytes.

doi:10.1016/0024-3205(92)90607-q

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Article

Effects of morphine on the phenotypic expression of cell surface markers on murine lymphocytes.

Life sciences - 1 Jan 1992

Kimes A S, Smith W J, Winchell C J, London E D

Abstract excerpt

There is a growing literature indicating that opioid abuse by human addicts and opioid administration to animals have profound effects on the immune system. In the present study, implantation of morphine pellets in mice was associated with reduced phenotypic expression of the cell surface antigen...

Topics

Animals
Antigens, Surface
Body Weight
Dose-Response Relationship, Drug
Leukocyte Count
Male
Mice
Mice, Inbred C57BL
Morphine
Organ Size
Phenotype
Spleen
T-Lymphocyte Subsets
T-Lymphocytes
T-Lymphocytes, Helper-Inducer
T-Lymphocytes, Regulatory
Time Factors

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