Article
The 4154delA mutation carriers in the BRCA1 gene share a common ancestry.
Familial cancer - 1 Jan 2009
Ozolina Silvija, Sinicka Olga, Jankevics Eriks, Inashkina Inna, Lubinski Jan, Gorski Bohdan, Gronwald Jacek, Nasedkina Tatyana, Fedorova Olga, Lyubchenko Ludmila, Tihomirova Laima
Abstract excerpt
Uncertainty exists whether the 4154delA mutation of the BRCA1 gene detected in unrelated individuals from Latvia, Poland and Russia is a founder mutation with a common ancestral origin. To trace back this problem we analysed the mutation-associated haplotype of the BRCA1 intragenic SNPs as well as intragenic and nearby STR markers in mutation carriers from the aforementioned populations. The mutation-associated...
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