Article
Microsatellite haplotypes for cystic fibrosis: mutation frameworks and evolutionary tracers.
Human molecular genetics - 1 Jul 1993
Morral N, Nunes V, Casals T, Chillón M, Giménez J, Bertranpetit J, Estivill X
Abstract excerpt
Highly informative intragenic microsatellite markers within the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene allow the analysis of associations between specific mutations and haplotypes. We have analysed 440 Spanish CF families carrying 22 different CF mutations and have e...
Topics
- Base Sequence
- Biological Evolution
- Cystic Fibrosis
- Cystic Fibrosis Transmembrane Conductance Regulator
- DNA Mutational Analysis
- DNA, Satellite
- Genetic Markers
- Haplotypes
- Humans
- Linkage Disequilibrium
- Membrane Proteins
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid
- Spain