Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The role of Alu elements in causing BRCA1 structural variation and breast cancer susceptibility.

Genes & genomics - 1 Jan 2026

Yu Minjae, Jo Dahee, Shin Wonseok, Han Kyudong

Abstract excerpt

BRCA1 is a tumor suppressor gene encoding a protein which plays an essential role in the repair of DNA double strand break. Approximately 40% of its introns are composed of Alu elements. It is known that retrotransposons create an environment prone to non-allelic recombination (NAHR) between homologous sequences, which frequently cause deletion or duplication of exon(s) resulting in structural variations in the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alu Elements
Share to BRCA1 Protein
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to BRCA1 gene

Share to Genetic Predisposition to Disease

Share to Mutation

Source

Identifiers

PMID: 41247621
DOI: 10.1007/s13258-025-01708-w

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The role of Alu elements in causing BRCA1 structural variation and breast cancer susceptibility.PMID 41247621Read ↗

Genomic characterization of two large Alu-mediated rearrangements of the BRCA1 gene.Semantic proximity Read ↗

Large genomic rearrangements in BRCA1 and BRCA2: implications for patient care.Semantic proximity Read ↗

Identification and Characterization of New Alu Element Insertion in the BRCA1 Exon 14 Associated with Hereditary Breast and Ovarian Cancer.Semantic proximity Read ↗

Detection of a novel Alu-mediated BRCA1 exon 13 duplication in Chinese breast cancer patients and implications for genetic testing.Semantic proximity Read ↗

BRCA Mutations: The Achilles Heel of Breast, Ovarian and Other Epithelial CancersSemantic proximity Read ↗

Detection of structural variations and fusion genes in breast cancer samples using third-generation sequencingSemantic proximity Read ↗

BRCA Mutations-The Achilles Heel of Breast, Ovarian and Other Epithelial Cancers.Semantic proximity Read ↗

Use of deep whole-genome sequencing data to identify structure risk variants in breast cancer susceptibility genes.Semantic proximity Read ↗

Genomic rearrangements in the BRCA1 and BRCA2 genes.Semantic proximity Read ↗

The contribution of LARGE genomic rearrangements of BRCA1 and BRCA2 gene mutations in breast and ovarian cancer families in a clinical cohortSemantic proximity Read ↗

Defining the heterogeneity of unbalanced structural variation underlying breast cancer susceptibility by nanopore genome sequencing.Semantic proximity Read ↗

Heterogenous point mutations in the BRCA1 breast cancer susceptibility gene occur in high frequency at the site of homonucleotide tracts, short repeats and methylatable CpG/CpNpG motifs.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.