Article
Targeted mutation of Ncam to produce a secreted molecule results in a dominant embryonic lethality.
Proceedings of the National Academy of Sciences of the United States of America - 25 Jun 1996
Rabinowitz J E, Rutishauser U, Magnuson T
Abstract excerpt
The neural cell adhesion molecule (NCAM) is a membrane-associated member of the immunoglobulin superfamily capable of both homophilic and heterophilic binding. To investigate the significance of this binding, a gene targeting strategy in embryonic stem (ES) cells was used to replace the membrane-associated forms of NCAM with a soluble, secreted form of its extracellular domain. Although the heterozygous mutant ES...
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