Article
Disruption of C-terminal cytoplasmic domain of betaPS integrin subunit has dominant negative properties in developing Drosophila.
Molecular biology of the cell - 1 Apr 2002
Jannuzi Alison L, Bunch Thomas A, Brabant Marc C, Miller Steven W, Mukai Leona, Zavortink Michael, Brower Danny L
Abstract excerpt
We have analyzed a set of new and existing strong mutations in the myospheroid gene, which encodes the betaPS integrin subunit of Drosophila. In addition to missense and other null mutations, three mutants behave as antimorphic alleles, indicative of dominant negative properties. Unlike null alleles, the three antimorphic mutants are synthetically lethal in double heterozygotes with an inflated (alphaPS2) null...
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