Accumulation of deletions and point mutations in mitochondrial genome in degenerative diseases.

doi:10.1111/j.1749-6632.1996.tb39055.x

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Accumulation of deletions and point mutations in mitochondrial genome in degenerative diseases.

Annals of the New York Academy of Sciences - 15 Jun 1996

Tanaka M, Kovalenko S A, Gong J S, Borgeld H J, Katsumata K, Hayakawa M, Yoneda M, Ozawa T

Abstract excerpt

Accumulation of various mutations in the mitochondrial genome is proposed as an important contributor to aging and degenerative diseases. Extensive fragmentation of mtDNA was detected in association with increased 8-hydroxydeoxyguanosine content in the heart mitochondrial DNA (mtDNA) from a patient with premature aging and mitochondrial cardiomyopathy, who carried a mutation within the mitochondrial tRNA(Asp)...

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Accumulation of deletions and point mutations in mitochondrial genome in degenerative diseases.

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Accumulation of deletions and point mutations in mitochondrial genome in degenerative diseases.

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