Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Accumulation of deletions and point mutations in mitochondrial genome in degenerative diseases.

Annals of the New York Academy of Sciences - 15 Jun 1996

Tanaka M, Kovalenko S A, Gong J S, Borgeld H J, Katsumata K, Hayakawa M, Yoneda M, Ozawa T

Abstract excerpt

Accumulation of various mutations in the mitochondrial genome is proposed as an important contributor to aging and degenerative diseases. Extensive fragmentation of mtDNA was detected in association with increased 8-hydroxydeoxyguanosine content in the heart mitochondrial DNA (mtDNA) from a patie...

Topics

Aged
Aging
Genome
Humans
MELAS Syndrome
Male
Mitochondria
Mutation
Nerve Degeneration
Parkinson Disease

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 8687011
DOI: 10.1111/j.1749-6632.1996.tb39055.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8687011-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Accumulation of deletions and point mutations in mitochondrial genome in degenerative diseases.PMID 8687011Read ↗

Mechanism of somatic mitochondrial DNA mutations associated with age and diseases.Semantic proximity Read ↗

Diseases resulting from mitochondrial DNA point mutations.Semantic proximity Read ↗

A specific point mutation in the mitochondrial genome of Caucasians with MELAS.Semantic proximity Read ↗

The m.3244G>A mutation in mtDNA is another cause of progressive external ophthalmoplegia.Semantic proximity Read ↗

A rapid and sensitive PCR screening method for point mutations associated with mitochondrial encephalomyopathies.Semantic proximity Read ↗

A point mutation in the mitochondrial tRNA(Leu)(UUR) gene in MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes).Semantic proximity Read ↗

Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging.Semantic proximity Read ↗

Mutations in mitochondrial tRNA genes: a frequent cause of neuromuscular diseases.Semantic proximity Read ↗

Distinct clustering of point mutations in mitochondrial DNA among patients with mitochondrial encephalomyopathies and with Parkinson's disease.Semantic proximity Read ↗

Diabetic conditions induce intolerance to accumulation of pathogenic mitochondrial DNAsSemantic proximity Read ↗

The mitochondrial tRNA(Leu(UUR)) mutation in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS): genetic, biochemical, and morphological correlations in skeletal muscle.Semantic proximity Read ↗

Specific correlation between the wobble modification deficiency in mutant tRNAs and the clinical features of a human mitochondrial disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.