Article
Reduced response to activated protein C is associated with increased risk for cerebrovascular disease.
Annals of internal medicine - 15 Aug 1996
van der Bom J G, Bots M L, Haverkate F, Slagboom P E, Meijer P, de Jong P T, Hofman A, Grobbee D E, Kluft C
Abstract excerpt
BACKGROUND: Resistance to activated protein C (APC), which results from various factors, including a mutation in the gene for coagulant factor V, has been associated with increased risk for venous thrombosis. However, its relation to arterial disease is still not well defined. OBJECTIVE: To investigate the association of both response to APC and the factor V Leiden mutation with arterial disease. DESIGN:...
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