Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid.

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Article

Docosahexaenoic acid synthesis in human skin fibroblasts involves peroxisomal retroconversion of tetracosahexaenoic acid.

Journal of lipid research - 1 Nov 1995

Moore S A, Hurt E, Yoder E, Sprecher H, Spector A A

Abstract excerpt

The purpose of this study was to determine whether the formation of docosahexaenoic acid in human cells occurs through a pathway that involves 24-carbon n-3 fatty acid intermediates and retroconversion. Normal human skin fibroblasts synthesized radiolabeled docosahexaenoic acid from [1-(14)C]18:3...

Topics

Cells, Cultured
Docosahexaenoic Acids
Fatty Acids, Omega-3
Fatty Acids, Unsaturated
Fibroblasts
Humans
Microbodies
Mutation
Oxidation-Reduction
Reference Values
Skin
Zellweger Syndrome
alpha-Linolenic Acid

Source

Open in PubMed

Identifiers

PMID: 8656081

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8656081-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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