Article
Mutations in DNA polymerase beta mRNA of stilbene estrogen-induced kidney tumors in Syrian hamster.
Biochemistry and molecular biology international - 1 Sept 1995
Yan Z J, Roy D
Abstract excerpt
We report here the alteration(s) in the expression of the DNA repair gene, DNA polymerase beta, in kidney tumors induced by stilbene estrogen (diethylstilbestrol, DES). RT-PCR, slot blotting, and Northern blotting experiments revealed that expression of DNA polymerase beta (DNA pol beta) was several fold lower in stilbene-estrogen-induced kidney tumors than in age-matched controls. Several mutations were...
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