Article
Agouti alleles alter cysteine and glutathione concentrations in hair follicles and serum of mice (A y/a, A wJ/A wJ, and a/a).
The Journal of investigative dermatology - 1 Mar 1996
Granholm D E, Reese R N, Granholm N H
Abstract excerpt
Ectopic overexpression of the agouti protein in the lethal yellow (A y/a) mouse causes a yellow coat as well as the lethal yellow syndrome. Presence of thiols like glutathione (GSH) or cysteine (Cys) may regulate the conversion of dopaquinone to phaeomelanin in hair follicle melanocytes. GSH also...
Topics
- Agouti Signaling Protein
- Alleles
- Animals
- Cysteine
- Female
- Genes, Lethal
- Genotype
- Glutathione
- Hair Color
- Hair Follicle
- Intercellular Signaling Peptides and Proteins
- Mice
- Mice, Mutant Strains
- Phenotype
- Proteins
- Syndrome