Three-dimensional co-culture of human monocytes and macrophages with tumor cells: analysis of macrophage differentiation and activation.

doi:10.1002/(SICI)1097-0215(19960529)66:5<645::AID-IJC11>3.0.CO;2-3

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Article

Three-dimensional co-culture of human monocytes and macrophages with tumor cells: analysis of macrophage differentiation and activation.

International journal of cancer - 29 May 1996

Konur A, Kreutz M, Knüchel R, Krause S W, Andreesen R

Abstract excerpt

Here we report on an experimental system for generating TAM in vitro by culturing human MO and MO-derived macrophages (MAC) within 3-dimensional multicellular tumor spheroids (MCS). MO as well as MO-derived MAC migrate into tumor spheroids and spread throughout the entire spheroid within 16 hr. I...

Topics

Antigens, Neoplasm
Base Sequence
Cell Differentiation
Coculture Techniques
Cytokines
GPI-Linked Proteins
Humans
Macrophage Activation
Macrophages
Metalloendopeptidases
Molecular Sequence Data
Monocytes
Phenotype
Polymerase Chain Reaction
RNA, Messenger
Spheroids, Cellular
Transcription, Genetic
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 8647627
DOI: 10.1002/(SICI)1097-0215(19960529)66:5<645::AID-IJC11>3.0.CO;2-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8647627-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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