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Inhibiting Monocyte Recruitment to Prevent the Pro-Tumoral Activity of Tumor-Associated Macrophages in Chondrosarcoma.

Cells - 24 Apr 2020

Minopoli Michele, Sarno Sabrina, Di Carluccio Gioconda, Azzaro Rosa, Costantini Susan, Fazioli Flavio, Gallo Michele, Apice Gaetano, Cannella Lucia, Rea Domenica, Stoppelli Maria Patrizia, Boraschi Diana, Budillon Alfredo, Scotlandi Katia, De Chiara Annarosaria, Carriero Maria Vincenza

Abstract excerpt

Chondrosarcomas (CHS) are malignant cartilaginous neoplasms with diverse morphological features, characterized by resistance to chemo- and radiation therapies. In this study, we investigated the role of tumor-associated macrophages (TAM)s in tumor tissues from CHS patients by immunohistochemistry. Three-dimensional organotypic co-cultures were set up in order to evaluate the contribution of primary human CHS...

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PMID: 32344648
DOI: 10.3390/cells9041062
PMCID: PMC7226304

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