Article
Advanced maternal age and the risk of Down syndrome characterized by the meiotic stage of chromosomal error: a population-based study.
American journal of human genetics - 1 Mar 1996
Yoon P W, Freeman S B, Sherman S L, Taft L F, Gu Y, Pettay D, Flanders W D, Khoury M J, Hassold T J
Abstract excerpt
The identification of DNA polymorphisms makes it possible to classify trisomy 21 according to the parental origin and stage (meiosis I [MI], meiosis II [MII], or postzygotic mitotic) of the chromosomal error. Studying the effect of parental age on these subgroups could shed light on parental expo...
Topics
- Adult
- Birth Rate
- Case-Control Studies
- Down Syndrome
- Female
- Genotype
- Georgia
- Humans
- Infant, Newborn
- Logistic Models
- Male
- Maternal Age
- Meiosis
- Mitosis
- Paternal Age
- Pregnancy, High-Risk
- Risk
- Trisomy