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Article

Genetic analysis of a poliovirus/hepatitis C virus chimera: new structure for domain II of the internal ribosomal entry site of hepatitis C virus.

Journal of virology - 1 Apr 2001

Zhao W D, Wimmer E

Abstract excerpt

Internal ribosomal entry sites (IRESs) of certain plus-strand RNA viruses direct cap-independent initiation of protein synthesis both in vitro and in vivo, as can be shown with artificial dicistronic mRNAs or with chimeric viral genomes in which IRES elements were exchanged from one virus to another. Whereas IRESs of picornaviruses can be readily analyzed in the context of their cognate genome by genetics, the...

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Identifiers

PMID: 11264361
DOI: 10.1128/JVI.75.8.3719-3730.2001
PMCID: PMC114863

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