Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin.

Biochemistry - 13 Feb 1996

Pechik I, Ji X, Fidelis K, Karavitis M, Moult J, Brinigar W S, Fronticelli C, Gilliland G L

Abstract excerpt

The crystal structure of the mutant deoxyhemoglobin in which the beta-globin Val67(E11) has been replaced with threonine [Fronticelli et al. (1993) Biochemistry 32, 1235-1242] has been determined at 2.2 A resolution. Prior to the crystal structure determination, molecular modeling indicated that the Thr67(E11) side chain hydroxyl group in the distal beta-heme pocket forms a hydrogen bond with the backbone...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Variation
Share to In Vitro Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Oxidation-Reduction

Share to Point Mutation

Share to Protein Conformation

Share to Protein Folding

Share to Protein Processing, Post-Translational

Source

Identifiers

PMID: 8639677
DOI: 10.1021/bi9519967

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Crystallographic, molecular modeling, and biophysical characterization of the valine beta 67 (E11)-->threonine variant of hemoglobin.PMID 8639677Read ↗

High-resolution crystal structures of human hemoglobin with mutations at tryptophan 37beta: structural basis for a high-affinity T-state,.Semantic proximity Read ↗

Biochemical characterization of a variant human medium-chain acyl-CoA dehydrogenase with a disease-associated mutation localized in the active site.Semantic proximity Read ↗

The role of Val68(E11) in ligand binding to sperm whale myoglobin. Site-directed mutagenesis of a synthetic gene.Semantic proximity Read ↗

Interactions among residues CD3, E7, E10, and E11 in myoglobins: attempts to simulate the ligand-binding properties of Aplysia myoglobin.Semantic proximity Read ↗

A myoglobin variant with a polar substitution in a conserved hydrophobic cluster in the heme binding pocket.Semantic proximity Read ↗

Structural and functional effects of apolar mutations of the distal valine in myoglobin.Semantic proximity Read ↗

Novel Redox Active Tyrosine Mutations Enhance the Regeneration of Functional Oxyhemoglobin from Methemoglobin: Implications for Design of Blood Substitutes.Semantic proximity Read ↗

Crystallographic analysis of mutant human haemoglobins made in Escherichia coli.Semantic proximity Read ↗

Functional properties of human hemoglobins synthesized from recombinant mutant beta-globins.Semantic proximity Read ↗

Hemoglobin Saint Mandé [beta 102 (G4) Asn----Tyr]. Functional studies and structural modeling reveal an altered T state.Semantic proximity Read ↗

Distal residues in the oxygen binding site of haemoglobin studied by protein engineering.Semantic proximity Read ↗

Characterization and structural analysis of a functional human serum transferrin variant and implications for receptor recognition.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.