Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Pax3 modulates expression of the c-Met receptor during limb muscle development.

30 Apr 1996

Abstract excerpt

Pax3 is a transcription factor whose expression has been used as a marker of myogenic precursor cells arising in the lateral somite destined to migrate to and populate the limb musculature. Accruing evidence indicates that the embryologic origins of axial and appendicular muscles are distinct, and limb muscle abnormalities in both mice and humans harboring Pax3 mutations support this distinction. The mechanisms...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hedgehog Signaling Pathway Studies
Share to Liver physiology and pathology
Share to Renal and related cancers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8633043
DOI: 10.1073/pnas.93.9.4213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Pax3 modulates expression of the c-Met receptor during limb muscle development.PMID 8633043Read ↗

The transcriptional activator PAX3-FKHR rescues the defects of Pax3 mutant mice but induces a myogenic gain-of-function phenotype with ligand-independent activation of Met signaling in vivo.Semantic proximity Read ↗

A novel genetic hierarchy functions during hypaxial myogenesis: Pax3 directly activates Myf5 in muscle progenitor cells in the limb.Semantic proximity Read ↗

Lbx1 is required for muscle precursor migration along a lateral pathway into the limb.Semantic proximity Read ↗

Lineage-specific responses to reduced embryonic Pax3 expression levels.Semantic proximity Read ↗

Divergent functions of murine Pax3 and Pax7 in limb muscle development.Semantic proximity Read ↗

Validation of Met as a Therapeutic Target in Alveolar and Embryonal RhabdomyosarcomaSemantic proximity Read ↗

Analysis of Mlc-lacZ Met mutants highlights the essential function of Met for migratory precursors of hypaxial muscles and reveals a role for Met in the development of hyoid arch-derived facial muscles.Semantic proximity Read ↗

The functions of HGF/SF and its receptor, the c-Met tyrosine kinase, in mammalian development.Semantic proximity Read ↗

The expression and function of PAX3 in development and disease.Semantic proximity Read ↗

Identification of a hypaxial somite enhancer element regulatingPax3 expression in migrating myoblasts and characterization of hypaxial muscle Cre transgenic miceSemantic proximity Read ↗

A crucial role for Pax3 in the development of the hypaxial musculature and the long-range migration of muscle precursors.Semantic proximity Read ↗

Klhl31 attenuates β-catenin dependent Wnt signaling and regulates embryo myogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.