Article
Two androgen response regions cooperate in steroid hormone regulated activity of the prostate-specific antigen promoter.
The Journal of biological chemistry - 15 Mar 1996
Cleutjens K B, van Eekelen C C, van der Korput H A, Brinkmann A O, Trapman J
Abstract excerpt
Transcription of the prostate-specific antigen (PSA) gene is androgen regulated. The PSA promoter contains at position -170 the sequence AGAACAgcaAGTGCT, which is closely related to the ARE (androgen response element) consensus sequence GGTACAnnnTGTTCT. This sequence is a high affinity androgen r...
Topics
- Androgens
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- Chromosome Mapping
- Consensus Sequence
- DNA
- Dexamethasone
- Humans
- Male
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Prostate-Specific Antigen
- Rats
- Receptors, Androgen
- Receptors, Glucocorticoid