Article
A G/A polymorphism in the androgen response element 1 of prostate-specific antigen gene correlates with the response to androgen deprivation therapy in Japanese population.
Anticancer research - 1 Jan 2000
Shibahara Takuji, Onishi Takehisa, Franco Omar E, Arima Kiminobu, Nishikawa Kohei, Yanagawa Makoto, Hioki Takuichi, Watanabe Masatoshi, Hirokawa Yoshifumi, Shiraishi Taizo, Sugimura Yoshiki
Abstract excerpt
Prostate-specific antigen (PSA) gene expression is regulated by androgen receptor (AR) through androgen response elements (AREs) in the promoter region of the PSA gene. A single nucleotide polymorphism with guanine (G) to adenine (A) substitution is identified at position -158 in the ARE of the PSA gene. The purpose of this study was to investigate the allelic differences in the PSA promoter activity in vitro and...
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