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Article

Testing for linkage disequilibrium in genotypic data using the Expectation-Maximization algorithm.

Heredity - 1 Apr 1996

Slatkin M, Excoffier L

Abstract excerpt

We generalize an approach suggested by Hill (Heredity, 33, 229-239, 1974) for testing for significant association among alleles at two loci when only genotype and not haplotype frequencies are available. The principle is to use the Expectation-Maximization (EM) algorithm to resolve double heterozygotes into haplotypes and then apply a likelihood ratio test in order to determine whether the resolutions of...

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Identifiers

PMID: 8626222
DOI: 10.1038/hdy.1996.55

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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