Article
An E-M algorithm and testing strategy for multiple-locus haplotypes.
American journal of human genetics - 1 Mar 1995
Long J C, Williams R C, Urbanek M
Abstract excerpt
This paper gives an expectation maximization (EM) algorithm to obtain allele frequencies, haplotype frequencies, and gametic disequilibrium coefficients for multiple-locus systems. It permits high polymorphism and null alleles at all loci. This approach effectively deals with the primary estimation problems associated with such systems; that is, there is not a one-to-one correspondence between phenotypic and...
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