An E-M algorithm and testing strategy for multiple-locus haplotypes.

Article

An E-M algorithm and testing strategy for multiple-locus haplotypes.

American journal of human genetics - 1 Mar 1995

Long J C, Williams R C, Urbanek M

Abstract excerpt

This paper gives an expectation maximization (EM) algorithm to obtain allele frequencies, haplotype frequencies, and gametic disequilibrium coefficients for multiple-locus systems. It permits high polymorphism and null alleles at all loci. This approach effectively deals with the primary estimati...

Topics

Algorithms
Alleles
Chromosome Mapping
Data Interpretation, Statistical
Genotype
Haplotypes
Humans
Linkage Disequilibrium
Models, Genetic
Phenotype

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