Article
Dual phenotypic expression of hepatocytes and bile ductular markers in developing and preneoplastic rat liver.
Carcinogenesis - 1 Feb 1996
Tee L B, Kirilak Y, Huang W H, Smith P G, Morgan R H, Yeoh G C
Abstract excerpt
This study supports the existence of a pluripotent liver stem cell population which has the potential to differentiate into hepatocytes and bile ductular cells. We compared the expression of hepatocyte-specific and bile ductular-specific markers in fetal and preneoplastic rat liver. L-pyruvate kinase (L-PK) and alpha glutathione S-transferase (GST) were used as adult hepatocyte-specific markers, while cytokeratin...
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