Article
Sequences within the early and late promoters of archetype JC virus restrict viral DNA replication and infectivity.
Virology - 1 Feb 1996
Daniel A M, Swenson J J, Mayreddy R P, Khalili K, Frisque R J
Abstract excerpt
Two forms of JC virus (JCV) have been isolated from its human host, an archetype found in kidney tissue and urine of nonimmunocompromised individuals and a rearranged type detected in lymphocytes and brain tissue of patients with and without progressive multifocal leukoencephalopathy. To investigate the hypothesis that alterations to the archetype transcriptional control region yield rearranged forms of the virus...
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