Article
Sequences within the early and late promoters of archetype JC virus restrict viral DNA replication and infectivity.
Virology - 1 Feb 1996
Daniel A M, Swenson J J, Mayreddy R P, Khalili K, Frisque R J
Abstract excerpt
Two forms of JC virus (JCV) have been isolated from its human host, an archetype found in kidney tissue and urine of nonimmunocompromised individuals and a rearranged type detected in lymphocytes and brain tissue of patients with and without progressive multifocal leukoencephalopathy. To investig...
Topics
- Adult
- Cell Line
- Cell Line, Transformed
- Chloramphenicol O-Acetyltransferase
- DNA Replication
- DNA, Viral
- Gene Expression Regulation, Viral
- Genome, Viral
- Humans
- JC Virus
- Kidney Tubules, Proximal
- Mutation
- Neuroglia
- Promoter Regions, Genetic
- Recombination, Genetic
- Tumor Cells, Cultured
- Virion
- Virus Replication