Article
Peptide epitopes from noncytosolic Listeria monocytogenes can be presented by major histocompatibility complex class I molecules.
Infection and immunity - 1 May 1996
Zwickey H L, Potter T A
Abstract excerpt
Listeria monocytogenes is an intracellular pathogen which escapes the phagosome and resides in the cytosol of the host cell. Using Listeria innocua and a mutant strain of L. monocytogenes (listeriolysin O negative), which do not enter the cytosol of the host cell, we demonstrate class I presentation of an epitope of p60, a protein secreted by L. monocytogenes, to a class I-restricted CD8+ cytotoxic T lymphocyte...
Topics
- Animals
- Antigen Presentation
- Antigen-Presenting Cells
- Antigens, Bacterial
- Bacterial Toxins
- CD8-Positive T-Lymphocytes
- Cell Line
- Cytosol
- Cytotoxicity, Immunologic
- Epitopes
- Heat-Shock Proteins
- Hemolysin Proteins
- Histocompatibility Antigens Class I
- In Vitro Techniques