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Article

Dominance of conserved B-cell epitopes of the Plasmodium falciparum merozoite surface protein, MSP1, in blood-stage infections of naive Aotus monkeys.

Infection and immunity - 1 May 1996

Hui G S, Nikaido C, Hashiro C, Kaslow D C, Collins W E

Abstract excerpt

We have shown that conserved B epitopes were immunodominant in animals hyperimmunized with parasite-purified or recombinant merozoite surface protein MSP1 of Plasmodium falciparum. Cross-priming studies also suggested that a conserved T-helper epitope(s) is efficient in inducing the anti-MSP1 antibody response. In this study, we determined whether a similar profile of immune responses was induced during live P....

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Identifiers

PMID: 8613353
DOI: 10.1128/iai.64.5.1502-1509.1996
PMCID: PMC173954

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