Article
Dominance of conserved B-cell epitopes of the Plasmodium falciparum merozoite surface protein, MSP1, in blood-stage infections of naive Aotus monkeys.
Infection and immunity - 1 May 1996
Hui G S, Nikaido C, Hashiro C, Kaslow D C, Collins W E
Abstract excerpt
We have shown that conserved B epitopes were immunodominant in animals hyperimmunized with parasite-purified or recombinant merozoite surface protein MSP1 of Plasmodium falciparum. Cross-priming studies also suggested that a conserved T-helper epitope(s) is efficient in inducing the anti-MSP1 ant...
Topics
- Alleles
- Animals
- Antibodies, Protozoan
- Antigens, Protozoan
- Antigens, Surface
- Aotus trivirgatus
- B-Lymphocytes
- Binding, Competitive
- Enzyme-Linked Immunosorbent Assay
- Genetic Variation
- Immunodominant Epitopes
- Malaria, Falciparum
- Merozoite Surface Protein 1
- Plasmodium falciparum