Article
Polymorphism of the glycogen synthase gene in hypertensive and normotensive subjects.
Hypertension (Dallas, Tex. : 1979) - 1 Jan 1996
Schalin-Jäntti C, Nikula-Ijäs P, Huang X, Lehto M, Knudsen P, Syvänne M, Lehtovirta M T, Tikkanen T, Tikkanen I, Groop L C
Abstract excerpt
Hypertension and non-insulin-dependent diabetes mellitus (NIDDM) are characterized by a strong genetic component and impaired ability to store glucose as glycogen in skeletal muscle. Impaired insulin activation and altered genetic control of muscle glycogen synthase, the rate-limiting enzyme for glucose storage in skeletal muscle, could provide an explanation for this insulin resistance. We examined whether there...
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