Article
In vivo distribution of integrins in renal cell carcinoma: integrin-phenotype alteration in different degrees of tumor differentiation and VLA-2 involvement in tumor metastasis.
Cancer biotherapy - 1 Jan 1995
Anastassiou G, Duensing S, Steinhoff G, Kirchner H, Ganser A, Atzpodien J
Abstract excerpt
We studied 23 renal cell carcinomas and two normal kidney tissues by immunohistochemistry using monoclonal antibodies against subunits of the VLA integrins (VLA-1 to VLA-6) and CD51. All integrins investigated in our study, except VLA-4 (ubiquitous negative), were distributed in different pattern...
Topics
- Adult
- Aged
- Antibodies, Monoclonal
- Carcinoma, Renal Cell
- Cell Differentiation
- Cell Nucleus
- Female
- Humans
- Immunoenzyme Techniques
- Kidney
- Kidney Neoplasms
- Male
- Middle Aged
- Phenotype
- Prognosis
- Receptors, Very Late Antigen