Article
Erythrocyte pyruvate kinase deficiency. The influence of physiologically important metabolites on the function of normal and defective enzymes.
Enzyme & protein - 1 Jan 2000
Lakomek M, Winkler H, Pekrun A, Krüger N, Sander M, Huppke P, Schröter W
Abstract excerpt
The dependence of the erythrocyte pyruvate kinase (PK)-catalyzed reaction on the glycolytic intermediates glucose-6-phosphate (Gluc-6-P), 2,3-diphosphoglycerate (2,3-DPG) and the nucleotides ADP and ATP was studied in normal individuals and 14 patients with PK deficiency. The Gluc-6-P concentrati...
Topics
- 2,3-Diphosphoglycerate
- Adenosine Diphosphate
- Adenosine Triphosphate
- Adolescent
- Adult
- Allosteric Regulation
- Anemia, Hemolytic, Congenital
- Child
- Diphosphoglyceric Acids
- Enzyme Inhibitors
- Erythrocytes
- Female
- Glucose-6-Phosphate
- Glucosephosphates
- Hemoglobins
- Humans
- Kinetics
- Male