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Article

Red cell pyruvate kinase deficiency: from genetics to clinical manifestations.

Bailliere's best practice & research. Clinical haematology - 1 Mar 2000

Zanella A, Bianchi P

Abstract excerpt

Pyruvate kinase deficiency is the most frequent enzyme abnormality of the Embden-Meyerhof pathway causing hereditary non-spherocytic haemolytic anaemia. The degree of haemolysis varies widely, ranging from very mild or fully compensated forms, to life-threatening neonatal anaemia and jaundice necessitating exchange transfusions. Splenectomy should be reserved for young patients who require regular blood...

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Source

Identifiers

PMID: 10916678
DOI: 10.1053/beha.1999.0057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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