Imaging of Skeletal Disorders Caused by Fibroblast Growth Factor Receptor Gene Mutations.

Abstract excerpt

Fibroblast growth factors and fibroblast growth factor receptors (FGFRs) play important roles in human axial and craniofacial skeletal development. FGFR1, FGFR2, and FGFR3 are crucial for both chondrogenesis and osteogenesis. Mutations in the genes encoding FGFRs, types 1-3, are responsible for various skeletal dysplasias and craniosynostosis syndromes. Many of these disorders are relatively common in the...

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• Share to Bone Diseases
• Share to Child
• Share to Diagnosis, Differential
• Share to FGFR1 gene
• Share to Genetic Predisposition to Disease
• Share to Mutation
• Share to Receptors, Fibroblast Growth Factor
• Share to Syndrome