Article
Altered calcium currents in human hypokalemic periodic paralysis myotubes expressing mutant L-type calcium channels.
Society of General Physiologists series - 1 Jan 1995
Lehmann-Horn F, Sipos I, Jurkat-Rott K, Heine R, Brinkmeier H, Fontaine B, Kovacs L, Melzer W
Abstract excerpt
In a genome-wide search, linkage of hypokalemic periodic paralysis (HypoPP), a muscle disease with autosomal dominant inheritance, to chromosome 1q31-32 and cosegregation with the gene encoding the L-type calcium channel/DHP receptor alpha 1 subunit has been reported (Fontaine et al., 1994). Here...
Topics
- Calcium Channels
- Cells, Cultured
- DNA, Complementary
- Electrophysiology
- Gene Expression
- Humans
- Hypokalemia
- Muscular Diseases
- Mutation
- Paralyses, Familial Periodic
- Patch-Clamp Techniques
- Proteins