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Article

A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.

Neuroscience letters - 20 Oct 1995

Escorihuela R M, Fernández-Teruel A, Vallina I F, Baamonde C, Lumbreras M A, Dierssen M, Tobeña A, Flórez J

Abstract excerpt

Mice which are trisomic for only the human chromosome (Chr) 21-homologous segment of mouse Chr 16 (segmental trisomy), including a portion of the Down syndrome region of human Chr 21, have recently been developed. Since these segmentally trisomic mice, designated Ts(17(16))65Dn, survive to adulthood, they may represent a mouse model for the study of Down syndrome. A partial characterization of their behavioral...

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Source

Identifiers

PMID: 8584244
DOI: 10.1016/0304-3940(95)12052-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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A behavioral assessment of Ts65Dn mice: a putative Down syndrome model.PMID 8584244Read ↗

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Cognitive, Behavioral, and Sleep Characterization of Sex Differences in the Ts65Dn Mouse Model of Down syndromeSemantic proximity Read ↗

Nest building is impaired in the Ts65Dn mouse model of Down syndrome and rescued by blocking 5HT2a receptors.Semantic proximity Read ↗

Ts65Dn mice, a model for Down syndrome, have deficits in context discrimination learning suggesting impaired hippocampal function.Semantic proximity Read ↗

Understanding mental retardation in Down's syndrome using trisomy 16 mouse modelsSemantic proximity Read ↗

Trisomy of Human Chromosome 21 Orthologs Mapping to Mouse Chromosome 10 Cause Age and Sex-Specific Learning Differences: Relevance to Down Syndrome.Semantic proximity Read ↗

Ts66Yah, an upgraded Ts65Dn mouse model for Down syndrome, for only the region homologous to Human chromosome 21Semantic proximity Read ↗

Perinatal loss of Ts65Dn Down syndrome mice.Semantic proximity Read ↗

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