Article
The major histocompatibility complex influences the development of chronic liver disease in male children and young adults with cystic fibrosis.
Journal of hepatology - 1 Nov 1995
Duthie A, Doherty D G, Donaldson P T, Scott-Jupp R, Tanner M S, Eddleston A L, Mowat A P
Abstract excerpt
BACKGROUND/AIMS: Chronic liver disease is a well-recognised complication of cystic fibrosis. Recent reports suggest that its development is not determined by specific mutations within the cystic fibrosis gene; however, familial clustering of portal hypertension cases and inappropriate immune responses against liver membrane antigens demonstrated in children with cystic fibrosis and chronic liver disease suggest...
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