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Article

The ecdysone-inducible Broad-complex and E74 early genes interact to regulate target gene transcription and Drosophila metamorphosis.

Genetics - 1 Nov 1995

Fletcher J C, Thummel C S

Abstract excerpt

Pulses of the steroid hormone ecdysone initiate Drosophila metamorphosis by inducing widespread changes in gene expression. The Broad-Complex (BR-C) and E74 are induced directly by ecdysone and encode families of transcription factors that regulate ecdysone primary- and secondary-response genes. Genetic analyses have revealed that mutations in the BR-C and E74 are lethal during metamorphosis and that these...

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Identifiers

PMID: 8582609
DOI: 10.1093/genetics/141.3.1025
PMCID: PMC1206826

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The ecdysone-inducible Broad-complex and E74 early genes interact to regulate target gene transcription and Drosophila metamorphosis.PMID 8582609Read ↗

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