The Drosophila Broad-Complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis.

doi:10.1242/dev.118.3.977

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Article

The Drosophila Broad-Complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis.

Development (Cambridge, England) - 1 Jul 1993

Karim F D, Guild G M, Thummel C S

Abstract excerpt

During Drosophila third instar larval development, one or more pulses of the steroid hormone ecdysone activate three temporally distinct sets of genes in the salivary glands, represented by puffs in the polytene chromosomes. The intermolt genes are induced first, in mid-third instar larvae; these genes encode a protein glue used by the animal to adhere itself to a solid substrate for metamorphosis. The intermolt...

Topics

Alleles
Animals
DNA-Binding Proteins
Drosophila melanogaster
Ecdysone
Gene Expression Regulation
Genes, Insect
Genes, Overlapping
Glue Proteins, Drosophila
Larva
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Metamorphosis, Biological

Models, Genetic

Organ Culture Techniques

Promoter Regions, Genetic

Pupa

RNA, Messenger

Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 8076529
DOI: 10.1242/dev.118.3.977

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8076529-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The Drosophila Broad-Complex plays a key role in controlling ecdysone-regulated gene expression at the onset of metamorphosis.PMID 8076529Read ↗

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The role of the BR-C locus on the expression of genes located at the ecdysone-regulated 3C puff of Drosophila melanogaster.Semantic proximity Read ↗

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The ecdysone-induced puffing cascade in Drosophila salivary glands: a Broad-Complex early gene regulates intermolt and late gene transcription.Semantic proximity Read ↗

Transcription at the ecdysone-inducible locus 2B5 in Drosophila.Semantic proximity Read ↗

Dynamic expression of broad-complex isoforms mediates temporal control of an ecdysteroid target gene at the onset of Drosophila metamorphosis.Semantic proximity Read ↗

Relationships between protein isoforms and genetic functions demonstrate functional redundancy at the Broad-Complex during Drosophila metamorphosis.Semantic proximity Read ↗

Broad-Complex, E74, and E75 early genes control DNA puff BhC4-1 expression in prepupal salivary glands.Semantic proximity Read ↗

Anciently duplicated Broad Complex exons have distinct temporal functions during tissue morphogenesis.Semantic proximity Read ↗

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Control of Dopa decarboxylase gene expression by the Broad-Complex during metamorphosis in Drosophila.Semantic proximity Read ↗

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