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Article

Malignant hematopoietic cell lines: in vitro models for the study of myelodysplastic syndromes.

Leukemia research - 1 Feb 2000

Drexler H G

Abstract excerpt

The myelodysplastic syndromes (MDS) are clonal myeloid disorders characterized by bone marrow cell dysplasia and ineffective hematopoiesis leading to peripheral refractory cytopenias. The course of the disease ranges from a chronic status with progressively impaired hematopoiesis to rapid evolution to acute myeloid leukemia (AML). A panel of continuous malignant hematopoietic cell lines has been established from...

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PMID: 10654445
DOI: 10.1016/s0145-2126(99)90169-8

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