Article
The "n-1" model for myelodysplastic syndromes.
Leukemia research - 1 Jan 1992
Luzzatto L, Colonna F, Reilly I
Abstract excerpt
Current models of leukaemogenesis tend to visualize this process as consisting of several discrete steps. Since myelodysplastic syndromes (MDS) are, almost by definition, pre-leukaemic disorders, we expect that bone marrow from patients with MDS must contain cells which are one step short of full leukaemic transformation: we designate these cells, for convenience, as "n-1". It should be possible therefore to...
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