Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector.

doi:10.1089/hum.1995.6.11-1487

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Article

Modification of nasal epithelial potential differences of individuals with cystic fibrosis consequent to local administration of a normal CFTR cDNA adenovirus gene transfer vector.

Human gene therapy - 1 Nov 1995

Hay J G, McElvaney N G, Herena J, Crystal R G

Abstract excerpt

Mutations in the cystic fibrosis transmembrane conductance regulator gene (CFTR) manifest on the nasal epithelial surface of individuals with cystic fibrosis (CF) by Na+ hyperabsorption and diminished beta-agonist-induced Cl- conductance, resulting in an abnormal bioelectric phenotype across the...

Topics

Adenoviridae
Administration, Intranasal
Adult
Chlorides
Cystic Fibrosis
Cystic Fibrosis Transmembrane Conductance Regulator
DNA, Complementary
Epithelium
Female
Gene Transfer Techniques
Genetic Therapy

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Vectors

Humans

Male

Membrane Potentials

Nasal Cavity

Phenotype

Sodium

Source

Open in PubMed

Identifiers

PMID: 8573621
DOI: 10.1089/hum.1995.6.11-1487

Genes

CFTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8573621-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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