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Article

Functional significance of loops in the receptor binding domain of Bacillus thuringiensis CryIIIA delta-endotoxin.

Journal of molecular biology - 2 Feb 1996

Wu S J, Dean D H

Abstract excerpt

Analysis of the three surface loops in domain II of Bacillus thuringiensis CryIIIA delta-endotoxin has been carried out to assess their role in receptor binding and toxicity. Site-directed mutagenesis was used to convert loop residues to alanine and the mutant proteins were analyzed for structural stability, toxicity to beetle larvae (Tenebrio molitor), binding to receptors on T. molitor brush border membrane...

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Identifiers

PMID: 8568902
DOI: 10.1006/jmbi.1996.0052

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