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Article

Analysis of mutations in the pore-forming region essential for insecticidal activity of a Bacillus thuringiensis delta-endotoxin.

Journal of bacteriology - 1 Oct 1999

Kumar A S, Aronson A I

Abstract excerpt

The Bacillus thuringiensis insecticidal delta-endotoxins have a three-domain structure, with the seven amphipathic helices which comprise domain I being essential for toxicity. To better define the function of these helices in membrane insertion and toxicity, either site-directed or random mutagenesis of two regions was performed. Thirty-nucleotide segments in the B. thuringiensis cry1Ac1 gene, encoding parts of...

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Identifiers

PMID: 10498724
DOI: 10.1128/JB.181.19.6103-6107.1999
PMCID: PMC103639

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Source receipt: pubmed, retrieved 7 Sept 2026.

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