Article
All domains of Cry1A toxins insert into insect brush border membranes.
The Journal of biological chemistry - 26 Sept 2008
Nair Manoj S, Dean Donald H
Abstract excerpt
A critical step in understanding the mode of action of insecticidal crystal toxins from Bacillus thuringiensis is their partitioning into membranes and, in particular, the insertion of the toxin into insect brush border membranes. The Umbrella and Penknife models predict that only alpha-helix 5 of domain I along with adjacent helices alpha-4 or alpha-6 insert into the brush border membranes because of their...
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