Article
Basic principles and technologies for deciphering the genetic map of cancer.
World journal of surgery - 1 Apr 2009
Voidonikolas Georgios, Kreml Stephanie S, Chen Changyi, Fisher William E, Brunicardi F Charles, Gibbs Richard A, Gingras Marie-Claude
Abstract excerpt
The progress achieved in the field of genomics in recent years is leading medicine to adopt a personalized model in which the knowledge of individual DNA alterations will allow a targeted approach to cancer. Using pancreatic cancer as a model, we discuss herein the fundamentals that need to be considered for the high throughput and global identification of mutations. These include patient-related issues, sample...
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