Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusion

1 Feb 1996

Abstract excerpt

We have studied an acute promyelocytic leukemia (APL) patient with a variant t(5;17)(q32;q12). This translocation fuses the gene for the nucleolar phosphoprotein nucleophosmin (NPM) to the retinoic acid receptor alpha (RARA). Two alternatively spliced transcripts are expressed, which differ in 129 bases immediately upstream of the RARA sequence. The NPM sequences contained in the shorter NPM-RAR cDNA are...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acute Myeloid Leukemia Research
Share to Antioxidant Activity and Oxidative Stress
Share to Retinoids in leukemia and cellular processes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8562957
DOI: 10.1182/blood.v87.3.882.bloodjournal873882

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The t(5;17) variant of acute promyelocytic leukemia expresses a nucleophosmin-retinoic acid receptor fusionPMID 8562957Read ↗

Clinical and molecular features of acute promyelocytic leukemia with variant retinoid acid receptor fusionsSemantic proximity Read ↗

The Signal Transducer and Activator of Transcription STAT5b Gene Is a New Partner of Retinoic Acid Receptor in Acute Promyelocytic-Like LeukaemiaSemantic proximity Read ↗

Expression pattern of the RAR alpha-PML fusion gene in acute promyelocytic leukemia.Semantic proximity Read ↗

Optical Genome Mapping Reveals Complex and Cryptic Rearrangement Involving PML::RARA Fusion in Acute Promyelocytic LeukemiaSemantic proximity Read ↗

Reverse transcription polymerase chain reaction for the rearranged retinoic acid receptor alpha clarifies diagnosis and detects minimal residual disease in acute promyelocytic leukemia.Semantic proximity Read ↗

BCOR as a novel fusion partner of retinoic acid receptor alpha in a t(X;17)(p11;q12) variant of acute promyelocytic leukemiaSemantic proximity Read ↗

Uncovering the <em>PML::RARA </em>Fusion in Cytogenetically Cryptic and FISH-Negative Acute Promyelocytic Leukemia - A Case Report and Comprehensive Literature ReviewSemantic proximity Read ↗

Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia.Semantic proximity Read ↗

Rearrangements of the retinoic acid receptor alpha and promyelocytic leukemia zinc finger genes resulting from t(11;17)(q23;q21) in a patient with acute promyelocytic leukemia.Semantic proximity Read ↗

Rearrangements and aberrant expression of the retinoic acid receptor alpha gene in acute promyelocytic leukemias.Semantic proximity Read ↗

How retinoic acid and arsenic transformed acute promyelocytic leukemia therapySemantic proximity Read ↗

Clinical and molecular characterization of a rare syndrome of acute promyelocytic leukemia associated with translocation (11;17)Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.