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Article

Induction of cyclophosphamide-resistance by aldehyde-dehydrogenase gene transfer

1 Feb 1996

Abstract excerpt

The identification of genes inducing resistance to anticancer chemotherapeutic agents and their introduction into hematopoietic cells represents a promising approach to overcome bone marrow toxicity, the limiting factor for most high-dose chemotherapy regimens. Because resistance to cyclophosphamide has been correlated with increased levels of expression of the aldehyde-dehydrogenase (ALDH1) gene in tumor cell...

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Identifiers

PMID: 8562935
DOI: 10.1182/blood.v87.3.1097.bloodjournal8731097

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