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Article

Noninvasive Fetal HPA Genotyping for FNAIT: Diagnostic Accuracy and Technical Performance of Molecular Methods.

Transfusion medicine reviews - 1 Jul 2026

Valentin Alicia, Windhorst Anita C, Sachs Ulrich J, Wienzek-Lischka Sandra, Bedei Ivonne, Wolter Aline, Axt-Fliedner Roland

Abstract excerpt

Noninvasive fetal human platelet antigen (HPA) genotyping has emerged as a promising tool for diagnosing fetal and neonatal alloimmune thrombocytopenia (FNAIT). Detection of fetal HPA incompatibility using cell-free fetal DNA from maternal blood allows for early, risk-adapted clinical assessment. This review evaluates the diagnostic accuracy, technical performance, and clinical applicability of noninvasive fetal...

Read the complete abstract on PubMed

Topics

Humans
Female
Pregnancy
Antigens, Human Platelet
Thrombocytopenia, Neonatal Alloimmune
Genotyping Techniques

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Genotype

High-Throughput Nucleotide Sequencing

Source

Identifiers

PMID: 42435657
DOI: 10.1016/j.tmrv.2026.151017

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 18 Oct 2026.

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